Diastereoselective Synthesis of Cyclopenta[c]furans by a Catalytic Multicomponent Reaction
نویسندگان
چکیده
A diastereoselective three-component reaction between alkynyl enones, aldehydes and secondary amines is reported. With the aid of a benign indium catalyst, a range of highly substituted cyclopenta[c]furan derivatives can be obtained in a single-step procedure. The formation of the stereodefined heterocyclic motifs takes place via in situ generation of enamines followed by two sequential cyclization steps.
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